Study of the effect of thiourea and N-ethyl groups on antibacterial activity of rhodamine-labeled 3,4-HPO iron chelators against Gram ( plus /-) bacteria

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Moniz, T (Autor) Outra; Feio, M (Autor) Outra; Silva, D (Autor) Outra; de Castro, B (Autor) Outra; Maria Rangel (Autor) ICBAS

Revista

Título: Medicinal Chemistry Research

Vol. 27

Páginas: 1472-1477

ISSN: 1054-2523

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-00N-QZF

DOI: 10.1007/s00044-018-2165-1

Abstract (EN): In the sequence of the work in which we identified functional groups of rhodamine labeled 3,4-HPO chelators that are crucial for their activity against Mycobacterium avium infection we now scrutinize if the same groups are also relevant for the chelators antibacterial activity against Gram (+/-) bacteria. In this new infection scenario, we confirmed that a thiourea linkage and N-ethyl substituents on the xanthene ring are important and there is an advantage of the association of both groups in the molecular framework. In particular, we found that three hexadentate chelators (MRH7, MRH8, and MRH10) inhibit bacterial growth of Staphylococcus (S). aureus ATCC 25923 and S. epidermis ATCC 12228 and one hexadentate chelator (MRH7) also inhibits the growth of Escherichia (E.) coli ATCC 25922.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6