Determination of salivary cotinine as tobacco smoking biomarker

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Ramdzan, AN (Autor) Outra; Almeida, MIGS (Autor) Outra; McCullough, MJ (Autor) Outra; Marcela A Segundo (Autor) FFUP; Kolev, SD (Autor) Outra

Revista

Título: TrAC - Trends in Analytical Chemistry

Vol. 105

Páginas: 89-97

ISSN: 0165-9936

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00P-DFY

DOI: 10.1016/j.trac.2018.04.015

Abstract (EN): Cotinine, the first metabolite of nicotine, is often used as a biomarker in the monitoring of environmental tobacco smoke (ETS) exposure due to its longer half-life. The use of saliva to measure the concentration of cotinine is an attractive alternative to conventional biological matrices (such as blood and urine) due to its simple and non-invasive collection method. However, the detection of minute concentrations of cotinine in saliva poses a significant challenge. This review critically assesses the advantages and disadvantages of the most frequently used sample pre-treatment and detection methods for the analysis of salivary cotinine.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9