Review: Gastric malignancies: Basic aspects

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Camargo, MC (Autor) Outra; Figueiredo C (Autor) FMUP; Machado JC (Autor) FMUP

Revista

Título: Helicobacter

Vol. 24

ISSN: 1083-4389

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-00R-1A2

DOI: 10.1111/hel.12642

Abstract (EN): Gastric cancer is the third deadliest cancer in the world, and the absolute number of cases is increasing every year due to aging and growing of high-risk populations. This disease is a consequence of the complex interaction of microbial agents, with environmental and host factors, resulting in the dysregulation of multiple oncogenic and tumor-suppressing signaling pathways. Despite the advances in our understanding of carcinogenesis, there are still reduced therapeutic options for patients with gastric cancer. In recent years, genomic analyses of gastric tumors have emphasized their molecular heterogeneity. The distinction of gastric cancer molecular subtypes may be a key to identify novel therapeutic targets, to predict patient outcome and response to therapy, and to guide early diagnosis strategies. In this review, we summarize the most recent updates on the relationship between microbial agents and gastric cancer, in particular, Helicobacter pylori, the non-H pylori microbiome, and Epstein-Barr virus. We also highlight the main advances made in the past year regarding the molecular characterization of gastric cancer, especially the signatures with potential clinical utility. © 2019 John Wiley & Sons Ltd

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5