A role for hepcidin in the anemia caused by Trypanosoma brucei infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Neves, JV (Autor) Outra; Gomes, AC (Autor) Outra; Costa, DM (Autor) Outra; Barroso, C (Autor) Outra; Vaulont, S (Autor) Outra; Anabela Cordeiro da Silva (Autor) FFUP; Tavares, J (Autor) Outra; Rodrigues, P (Autor) ICBAS

Revista

Título: Haematologica

Vol. 106

Páginas: 806-818

ISSN: 0390-6078

Editora: FERRATA STORTI FOUNDATION

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00R-TD1

DOI: 10.3324/haematol.2019.227728

Abstract (EN): Trypanosomiasis is a parasitic disease affecting both humans and animals in the form of Human African Trypanosomiasis and Nagana disease, respectively. Anemia is one of the most common symptoms of trypanosomiasis, and if left unchecked can cause severe complications and even death. Several factors have been associated with the development of this anemia, including dysregulation of iron homeostasis, but little is known about the molecular mechanisms involved. Here, using murine models, we study the involvement of hepcidin, the key regulator of iron metabolism and an important player in the development of anemia of inflammation. Our data show two stages for the progression of anemia, to which hepcidin contributes a first stage when anemia develops, with a likely cytokine-mediated stimulation of hepcidin and subsequent limitation in iron availability and erythropoiesis, and a second stage of recovery, where the increase in hepcidin then declines due to the reduced inflammatory signal and increased production of erythroid regulators by the kidney, spleen and bone marrow, thus leading to an increase in iron release and availability, and enhanced erythropoiesis. In agreement with this, in hepcidin knockout mice, anemia is much milder and its recovery is complete, in contrast to wild-type animals which have not fully recovered from anemia after 21 days. Besides all other factors known to be involved in the development of anemia during trypanosomiasis, hepcidin clearly makes an important contribution to both its development and recovery.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13