BRCA1/P53: Two strengths in cancer chemoprevention

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Raimundo, L (Autor) Outra; Ramos, H (Autor) Outra; Loureiro, JB (Autor) Outra; Calheiros, J (Autor) Outra; Lucilia Saraiva (Autor) FFUP

Revista

Título: Biochimica et Biophysica Acta - Reviews on Cancer

Vol. 1873

ISSN: 0304-419X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00R-MCK

DOI: 10.1016/j.bbcan.2020.188339

Abstract (EN): Increasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. This review affords a critical and up-to-date discussion of issues related to cancer prevention, including an in-depth knowledge on BRCA1 and p53 tumor suppressor proteins as key molecular players. Indeed, it compiles the most recent advances on the topic, highlighting the unique potential of BRCA1 and p53 germline mutations as molecular biomarkers for risk assessment and targets for chemoprevention. Relevant evidences are herein provided supporting the effectiveness of distinct pharmacological agents in cancer prevention, by targeting BRCA1 and p53. Moreover, the rationale for using germline mutant BRCA1- or p53-related cancer syndromes as model systems to investigate effective chemopreventive agents is also addressed. Altogether, this work provides an innovative conception about the dependence on p53 and BRCA1 co-inactivation in tumor formation and development, emphasizing the relationship between these two proteins as an encouraging direction for future personalized pharmacological interventions in cancer prevention.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16