Weight loss achieved by bariatric surgery modifies high-density lipoprotein subfractions and low-density lipoprotein oxidation towards atheroprotection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Coimbra, S (Autor) Outra; Reis, F (Autor) Outra; Ferreira, C (Autor) Outra; Nunes, S (Autor) Outra; Viana, S (Autor) Outra; Catarino, A (Autor) Outra; Rocha Pereira, P (Autor) Outra; Belo, L (Autor) FFUP; Monteiro, L (Autor) Outra; Cristina Catarino (Autor) FFUP; Alice Santos Silva (Autor) FFUP

Revista

Título: Clinical Biochemistry

Vol. 63

Páginas: 46-53

ISSN: 0009-9120

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 10 Citações

Outras Informações

ID Authenticus: P-00P-SJ3

DOI: 10.1016/j.clinbiochem.2018.10.007

Abstract (EN): Objectives: Weight loss achieved by laparoscopic adjustable gastric banding (LAGB) induces an increase in high-density lipoprotein cholesterol (HDLc) but a small effect on low-density lipoprotein (LDL), although changes in their quality (size and composition) are uncertain. Our aim was to study the impact of weight loss, achieved 13-months after LAGB, on inflammation and dyslipidemia, focusing on HDL and LDL subfractions, and oxidized LDL (oxLDL). Design & methods: We evaluated standard lipid profile, HDL and LDL subfractions, oxLDL, interleukin (IL)-6 and C-reactive protein (CRP), in twenty obese patients, before (T0) and 13-months after LAGB (T1), and in seventeen healthy controls. Results: At T1, patients showed lower body weight (12% median weight loss) and anthropometric indices; reduction in TG, atherogenic indices, oxLDL, oxLDL/LDL ratio, CRP and IL-6, and enhancement in HDLc; an increase in large HDL and intermediate HDL subfractions, and a decrease in small HDL subtraction; LDL subfractions were not modified. Percentual change (%Delta) of oxLDL, from T0 to T1, correlated significantly and positively with %Delta of small HDL subfraction and with %Delta of body mass index. Conclusions: Weight loss induced atheroprotective changes on inflammation, and lipid profile, enhancing larger HDL, the more atheroprotective subfraction, reducing the less protective subclass, small HDL, and reducing oxLDL and oxLDL/LDL ratio. Quality of lipoproteins appears useful cardiovascular risk biomarkers, deserving further studies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8