Nonlinear adaptive control of the NeuroMuscular Blockade in anesthesia

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2011

Autores

da Silva, MM (Autor) Outra; Mendonca, T (Autor) FCUP; Wigren, T (Autor) Outra

Ata de Conferência Internacional

Título: 2011 50TH IEEE CONFERENCE ON DECISION AND CONTROL AND EUROPEAN CONTROL CONFERENCE (CDC-ECC)

Páginas: 41-46

50th IEEE Conference of Decision and Control (CDC)/European Control Conference (ECC)

Orlando, FL, DEC 12-15, 2011

Indexação

ISI Web of Knowledge - 5 Citações

Outras Informações

ID Authenticus: P-002-WDN

Abstract (EN): This paper presents a nonlinear adaptive control strategy based on the Wiener model for control of the NeuroMuscular Blockade in anesthesia. The structure combines the inversion of the static nonlinearity present in the Wiener model with a pole-placement controller for the linearized system. The overall strategy exploits identification of a minimally parameterized model for the description of the effect of the muscle relaxant atracurium in the NeuroMuscular Blockade. An Extended Kalman Filter was developed for that purpose, providing estimates of the model parameters for both the linear controller and the blocks where the inversion of the static linearity is performed. Simulations were run in a database of 100 patients simulated with the standard physiologically-based pharmacokinetic/pharmacodynamic model for the NeuroMuscular Blockade. The results show that the nonlinear adaptive controller performs well regarding reference following and tackles changes in the patient's dynamics. Noisy scenarios were also simulated to test the robustness of the proposed strategy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6