Rational Design of Multi-Target Estrogen Receptors ER alpha and ER beta by QSAR Approaches

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Zhao, Q (Autor) Outra; Lu, YX (Autor) Outra; Zhao, Y (Autor) Outra; Li, RC (Autor) Outra; Luan, F (Autor) Outra; Natalia N D S Cordeiro (Autor) FCUP

Revista

Título: Current Drug Targets

Vol. 18

Páginas: 576-591

ISSN: 1389-4501

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00M-E87

DOI: 10.2174/1389450117666160401125542

Abstract (EN): Estrogens play a crucial role in the growth, development, and homeostasis of various target tissues, their biological effects being mediated by the estrogen receptor (ER). In order to get a better understanding of the structural features of the modulators associated with the binding to ER, this paper provides an overview of the Quantitative Structure-Activity (QSAR) studies performed so far for estimating or predicting the activity of different ligands towards its two known subtypes (ER alpha and ER beta). Recent progresses in the application of these modeling studies are additionally pointed out. Finally, ongoing challenges that may lead to new and exciting directions for QSAR modeling studies in this field are discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16