Single dose versus multiple dose of antibiotic prophylaxis in caesarean section: a systematic review and meta-analysis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Pinto Lopes, R (Autor) Outra; Sousa Pinto, B (Autor) FMUP; Azevedo L (Autor) FMUP

Revista

Título: BJOG: An International Journal of Obstetrics and Gynaecology

Vol. 124

Páginas: 595-605

ISSN: 1470-0328

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 23 Citações

Scopus - 27 Citações

Outras Informações

ID Authenticus: P-00M-MHY

DOI: 10.1111/1471-0528.14373

Abstract (EN): Background Prophylactic antibiotics are traditionally given as a single dose for caesarean section. However, inconsistent application of recommendations and recent evidence prompted a literature review. Objectives To assess the optimal regimen for antibiotic prophylaxis in caesarean section by comparing single versus multiple doses of the same intervention. Search strategy MEDLINE, Web of Knowledge, SCOPUS, CENTRAL and ongoing trials databases were searched. Reference lists were reviewed and international groups contacted. Selection criteria Randomised controlled trials (RCT) comparing single with multiple dose regimens of the same antibiotic prophylaxis. Quasi-RCT and abstracts were suitable for inclusion. Data collection and analysis Reviewers independently extracted data and assessed quality of evidence. A random-effects model was used and results presented as risk ratio (RR) with 95% confidence intervals (CI). Main results Sixteen studies were included, involving 2695 women. Nonsignificant differences were observed between single dose and multiple dose antibiotic prophylaxis in the incidence of postpartum infectious morbidity (RR 0.95, 95% CI 0.75-1.20, I-2 = 25%), endometritis (RR 1.03, 95% CI 0.74-1.42, I-2 = 0%) and wound infection (RR 1.22, 95% CI 0.72-2.08, I-2 = 0%). A trend towards lower risk of urinary tract infection was seen with multiple dose (RR 0.65, 95% CI 0.34-1.24, I-2 = 0%). Conclusions There was insufficient evidence to determine whether there is a difference between single and multiple dose regimens in reducing the incidence of infectious morbidity after caesarean section. The quality of evidence was very low and well-designed RCTs are needed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11