Flavonoid Composition of Salacia senegalensis (Lam.) DC. Leaves, Evaluation of Antidermatophytic Effects, and Potential Amelioration of the Associated Inflammatory Response

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019-07

Autores

Nelson G. M. Gomes (Autor) FFUP; Andreia P. Oliveira (Autor) FFUP; Diana Cunha (Autor) Outra; David M. Pereira (Autor) FFUP; Patrícia Valentão (Autor) FFUP; Eugénia Pinto (Autor) FFUP; Luísa Araújo (Autor) Outra; Paula B. Andrade (Autor) FFUP

Revista

Título: Molecules

Vol. 24

Páginas: 2530-2530

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-00Q-SEQ

DOI: 10.3390/molecules24142530

Abstract (EN): Predominantly spread in West Tropical Africa, the shrub Salacia senegalensis (Lam.) DC. is known because of its medicinal properties, the leaves being used in the treatment of skin diseases. Prompted by the ethnomedicinal use, a hydroethanolic extract obtained from the leaves of the plant was screened against a panel of microbial strains, the majority of which involved in superficial infections. The extract was found to be active against the dermatophytes Trichophyton rubrum and Epidermophyton floccosum. Notable results were also recorded regarding the attenuation of the inflammatory response, namely the inhibitory effects observed against soybean 5-lipoxygenase (IC50 = 71.14 mu g mL(-1)), no interference being recorded in the cellular viability of RAW 264.7 macrophages and NO levels. Relevantly, the extract did not lead to detrimental effects against the keratinocyte cell line HaCaT, at concentrations displaying antidermatophytic and anti-inflammatory effects. Flavonoid profiling of S. senegalensis leaves was achieved for the first time, allowing the identification and quantitation of myricitrin, three 3-O-substituted quercetin derivatives, and three other flavonoid derivatives, which may contribute, at least partially, to the observed antidermatophytic and anti-inflammatory effects. In the current study, the plant S. senegalensis is assessed concerning its antidermatophytic and anti-inflammatory properties.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14