Anti-TNF-Alpha Induced Psoriasiform Eruptions with Severe Scalp Involvement and Alopecia: Report of Five Cases and Review of the Literature

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Osorio, F (Autor) Outra; Magro F (Autor) FMUP; Carmen Silva (Autor) FMUP; Lopes, S (Autor) Outra; Macedo G (Autor) FMUP; Bettencourt, H (Autor) Outra; Azevedo, F (Autor) Outra; magina, s (Autor) FMUP

Revista

Título: Dermatology

Vol. 225

Páginas: 163-167

ISSN: 1018-8665

Editora: Karger

Indexação

ISI Web of Knowledge - 25 Citações

Scopus - 37 Citações

Outras Informações

ID Authenticus: P-002-EQ3

DOI: 10.1159/000342503

Abstract (EN): We describe 5 cases of anti-tumor necrosis factor-alpha (anti-TNF-alpha) induced psoriasiform eruptions with severe scalp involvement inducing inflammatory alopecia and review the literature on this subject. All our 5 patients were provided topical therapy, with good results in only 1 case. The remaining 4 were provided systemic therapy (methotrexate +/- cyclosporine): 3 concomitantly suspended the anti-TNF-alpha treatment (2 are currently clear/almost clear but 1 has so far only observed mild improvement) and 1 switched anti-TNF-alpha (recurrent flare-ups of the disease continue). So far, no patient has developed scarring alopecia. To our knowledge, a total of 15 cases of anti-TNF-alpha induced psoriatic alopecia have been described. Anti-TNF-alpha was discontinued in 9 of the 15 patients and systemic therapy was provided to 9 of the 15 patients. Nonetheless, 2 patients developed scarring alopecia. We conclude that in anti-TNF-alpha induced psoriasiform eruptions some patients may respond to topical treatment, however in cases of severe scalp involvement anti-TNF-alpha suspension and systemic treatment should be considered in order to avoid scarring alopecia. Copyright (C) 2012 S. Karger AG, Basel

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5