Protein evolution of ANTP and PRD homeobox genes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Nuno A Fonseca (Autor) Outra; Cristina Vieira (Autor) Outra; Holland, PWH (Autor) Outra; Vieira, J (Autor) Outra

Revista

Título: BMC Evolutionary Biology

Vol. 8

Página Final: 200

ISSN: 1471-2148

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-003-XSD

DOI: 10.1186/1471-2148-8-200

Abstract (EN): Background: Although homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes. Results: In this study, we report a method for the fast and efficient retrieval of sequences belonging to the ANTP (HOXL and NKL) and PRD classes. Furthermore, we look for diagnostic amino acid residues that can be used to distinguish HOXL, NKL and PRD genes. Conclusion: The reported protein features will facilitate the robust classification of homeobox genes from newly sequenced bilaterian genomes. Nevertheless, in non-bilaterian genomes our findings must be cautiously applied. In principle, as long as a good manually curated data set is available the approach here described can be applied to non-bilaterian organisms as well. Our results help focus experimental studies onto investigating the biochemical functions of key homeodomain residues in different gene classes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10