BIOCHEMICAL AND GENETIC-STUDIES ON RABBIT HEMOGLOBIN .2. ELECTROPHORETIC POLYMORPHISM OF THE ALPHA-CHAIN

• Tipo: Artigo em Revista Científica Internacional
• Data: 1990

Autores

ferrand, n (Autor) FCUP

Revista

Título: Biochemical Genetics

Vol. 28

Páginas: 117-122

ISSN: 0006-2928

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-001-RVJ

DOI: 10.1007/bf00561331

Abstract (EN): A genetic polymorphism of rabbit (Oryctolagus cuniculus) hemoglobin ¿ chain is demonstrated by means of acid starch gel electrophoresis. The polymorphism is not detected by isoelectric focusing and may be based upon neutral for neutral amino acid substitutions in accordance with previous findings by means of amino acid sequencing. Segregation analysis was performed on 15 matings with 49 offspring and confirmed the initial genetic hypothesis of three common codominant alleles at an autosomal locus. The calculated gene frequencies in a random sample of 86 unrelated individuals are HBA*1 = 0.73, HBA*2 = 0.22, and HBA*3 = 0.05.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6