Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Benfeito, S (Autor) Outra; Oliveira, C (Autor) Outra; Fernandes, C (Autor) Outra; Fernando Cagide (Autor) FCUP; Teixeira, J (Autor) Outra; Amorim, R (Autor) Outra; Garrido, J (Autor) Outra; Martins, C (Autor) Outra; Sarmento, B (Autor) Outra; Silva, R (Autor) Outra; Fernando Remiao (Autor) FFUP; Uriarte, E (Autor) Outra; Oliveira, PJ (Autor) Outra; Fernanda Borges (Autor) FCUP

Revista

Título: European Journal of Medicinal Chemistry

Vol. 167

Páginas: 525-545

ISSN: 0223-5234

Editora: Elsevier

Indexação

ISI Web of Knowledge - 33 Citações

Scopus - 35 Citações

Outras Informações

ID Authenticus: P-00Q-CM6

DOI: 10.1016/j.ejmech.2019.01.055

Abstract (EN): Alzheimer's disease is an irreversible, complex and progressive neurodegenerative disorder associated with oxidative stress and mitochondrial dysfunction. Exogenous antioxidants can be beneficial for decreasing oxidative stress, as they are able to reward the lack of efficacy of the endogenous defense systems and raise the overall antioxidant response in a pathological condition. Along our overarching project related with the design and development of potent and safe multi-target mitochondriotropic antioxidants, based on dietary antioxidants, novel derivatives were obtained. Overall, mitochondriotropic antioxidants showed remarkable antioxidant and chelating properties, presenting low cytotoxic effects on human differentiated neuronal (SH-SY5Y) and hepatocarcinoma (HepG2) cells and exhibited neuroprotective properties on SH-SY5Y cells against 6-hydroxydopamine (6-OHDA) or hydrogen peroxide (H2O2) oxidative insults. Moreover, compounds 58, 59, 62, 63, 66 and 67 were able to permeate a layer of hCMEC/D3 cells in a time-dependent manner. Mitochondriotropic antioxidant 67 stands out by its remarkable iron chelating and neuroprotective properties toward both H2O2 and 6-OHDA-induced oxidative damage, drug-like properties and BBB permeability.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21