Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Andre, A (Autor) Outra; Ruivo, R (Autor) Outra; Capitao, A (Autor) Outra; Froufe, E (Autor) Outra; Pascoa, I (Autor) Outra; Filipe F C Castro (Autor) FCUP; Santos, MM (Autor) FCUP

Revista

Título: Chemosphere

Vol. 182

Páginas: 753-761

ISSN: 0045-6535

Editora: Elsevier

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-00N-XRP

DOI: 10.1016/j.chemosphere.2017.05.064

Abstract (EN): In the present work we provide the first isolation and functional characterization of a RXR orthologue in an annelid species, the Platynereis dumerilii. Using an in vitro luciferase reporter assay we evaluated the annelid receptor ability to respond to ligand 9-cis-retinoic acid, TBT and TPT. Our results show that the annelid RXR responds to 9-cis-retinoic acid and to the organotins by activating reporter gene transcription. The findings suggest a conserved mode of action of the receptor in response to a common signaling molecule and modulation by organotin compounds between vertebrates and Lophotrochozoans.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9