Liposomal therapies in oncology: does one size fit all?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Sousa, I (Autor) Outra; Rodrigues, F (Autor) Outra; Prazeres, H (Autor) Outra; Lima, RT (Autor) Outra; Soares, P (Autor) FMUP

Revista

Título: Cancer Chemotherapy and Pharmacology

Vol. 82

Páginas: 741-755

ISSN: 0344-5704

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00P-HY7

DOI: 10.1007/s00280-018-3668-7

Abstract (EN): Liposomal therapies opened the chapter of nanomedicine, in 1995, with the approval of liposomal doxorubicin (Doxil((R))) for the treatment of numerous types of cancer. For the first time, liposomes permitted the employment of potent chemotherapeutic agents with improved pharmacokinetic and pharmacodynamic profiles, with less undesired side effects. Liposomal therapies allow the drug encapsulation and more selective delivery in the tumor bed, particularly due to the enhanced permeation and retention effect. These unique characteristics explain why liposomal therapies are being increasingly considered as alternatives in cancer therapy and represent an important research field with the recent approval for clinical use and emergent formulations in clinical trials. Even so, the response rate of liposomal therapies varies between 5 and 71%, and they are still indistinguishably given to every patient. As already well-demonstrated for conventional chemotherapies and targeted therapies, there is also the need for predictive biomarkers that allow a better use of liposomal drugs, with higher patient quality of life. Our aim in this review was to address the approved liposomal therapies and to summarize the information concerning possible predictive markers of response in their various clinical applications, to personalize each patient treatment and maximize its efficacy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15