Quality of Vancomycin for Injection Formulations in Brazil

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Secco, G (Autor) Outra; Sachetti, C (Autor) Outra; Rossato Grando, LG (Autor) Outra; Hahn, SR (Autor) Outra; Pagnussat, LR (Autor) Outra; Fresco, P (Autor) FFUP; Bertol, CD (Autor) Outra

Revista

Título: Current Pharmaceutical Analysis

Vol. 15

Páginas: 280-285

ISSN: 1573-4129

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00N-KJ4

DOI: 10.2174/1573412914666180116143232

Abstract (EN): Background: The presence of impurities in vancomycin compromised the safety and contributed to decrease of its use for years. In Brazil, vancomycin generic drug represents an option to reduce hospital costs. However, the controversy over the quality of these formulations and their relationship to effectiveness and safety raised concerns. Objective and Methods: To assess in vitro quality of vancomycin injections through uniformity of weight, pH, clarity of solution, microbiological assay and impurities determination by High Performance Liquid Chromatography (HPLC). Results: The samples were approved in the tests. Conclusion: The injectable formulations of vancomycin proved to be safe for use in hospital environment. This work contributes to increase health professional's confidence on generic vancomycin.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6