Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Silva, B (Autor) Outra; Pereira, JA (Autor) Outra; Sara Cravo (Autor) FFUP; Araujo, AM (Autor) Outra; Carla Fernandes (Autor) FFUP; Pinto, MMM (Autor) Outra; de Pinho, PG (Autor) FFUP; Fernando Remiao (Autor) FFUP

Revista

Título: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Vol. 1100

Páginas: 158-164

ISSN: 1570-0232

Editora: Elsevier

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 23 Citações

Outras Informações

ID Authenticus: P-00P-RD3

DOI: 10.1016/j.jchromb.2018.10.002

Abstract (EN): The enantioresolution of pentedrone and methylone was carried out at a multi-milligram scale by liquid chromatography on a Chiralpak AS (R) stationary phase. The excellent enantioresolution using this column allowed to collect highly pure enantiomeric fractions, achieving enantiomeric ratios higher than 98%. An overall recovery of 72% was achieved for pentedrone enantiomers and 80% for methylone. Furthermore, the absolute configuration of the enantiomers of both cathinones was determined for the first time by electronic circular dichroism (ECD) spectroscopy, with the aid of theoretical calculations, as (+)-(S) and (-)-(R)-pentedrone, and (-)-(S) and (+)-(R)-methylone.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7