Dysregulation of cellular microRNAs by human oncogenic viruses - implications for tumorigenesis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Joana M. O. Santos (Autor) Outra; Rui M. Gil da Costa (Autor) FEUP; Rui Medeiros (Autor) Outra

Revista

Título: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Vol. 1861 Nº 2

Páginas: 95-105

ISSN: 1874-9399

Editora: Elsevier

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Projetos Associados

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Outras Informações

ID Authenticus: P-00N-K9M

DOI: 10.1016/j.bbagrm.2018.01.017

Abstract (EN): Infection with certain animal and human viruses, often referred to as tumor viruses, induces oncogenic processes in their host. These viruses can induce tumorigenesis through direct and/or indirect mechanisms, and the regulation of microRNAs expression has been shown to play a key role in this process. Some human oncogenic viruses can express their own microRNAs; however, they all can dysregulate the expression of cellular microRNAs, facilitating their respective life cycles. The modulation of cellular microRNAs expression brings consequences to the host cells that may lead to malignant transformation, since microRNAs regulate the expression of genes involved in oncogenic pathways. This review focus on the mechanisms used by each human oncogenic virus to dysregulate the expression of cellular microRNAs, and their impact on tumorigenesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11