The N-butyl-N-4-hydroxybutyl nitrosamine mouse urinary bladder cancer model

• Tipo: Capítulo ou Parte de Livro
• Data: 2018

Autores

Paula A. Oliveira (Autor) Outra; Cármen Vasconcelos Nóbrega (Autor) Outra; Rui M. Gil da Costa (Autor) FEUP; Regina Arantes Rodrigues (Autor) Outra

Livro

Título: Urothelial Carcinoma. Methods in Molecular Biology

Páginas: 155-167

Editora: Humana Press

Indexação

Scopus

Outras Informações

DOI: 10.1007/978-1-4939-7234-0_13

Abstract (EN): Urinary bladder cancer (UBC) is a common and complex malignancy, with a multifactorial etiology, like environmental factors, such as cigarette smoking, occupational exposure, and genetic factors. UBC exhibits considerable genotypic and phenotypic heterogeneity. Among all UBC lesions, urothelial carcinoma is the most frequently observed histological type. Despite all the developments made in urologic oncology field, therapeutic options remain inadequate. There is urgency for the identification and development of new antineoplastic drugs to replace or improve current protocols and in vivo models have been proven to be essential for this step. There are different animal models of UBC: Spontaneous and experimentally induced models (genetically engineered, transplantable-xenograft and syngeneic animals- and chemically induced models). N-butyl-N(4-hydroxybutil)nitrosamine (BBN) is the most suitable reagent to generate chemically induced in vivo models of UBC and to study bladder carcinogenesis. BBN has proven, over the years, to be very realistic and reliable. It is bladder specific, and induces high tumor incidence. © Springer Science+Business Media LLC 2018.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13