Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Magda S. S. Moutinho (Autor) Outra; Sofia Aragão (Autor) Outra; Diogo Carmo (Autor) Outra; Fátima Casaca (Autor) Outra; Sandra Silva (Autor) Outra; Joana Ribeiro (Autor) Outra; Hugo Sousa (Autor) Outra; Isabel Pires (Autor) Outra; Felisbina Queiroga (Autor) Outra; Bruno Colaço (Autor) Outra; Rui Medeiros (Autor) Outra; Paula A. Oliveira (Autor) Outra; Carlos Lopes (Autor) Outra; Margarida M. S. M. Bastos (Autor) FEUP; Rui M. Gil da Costa Oliveira (Autor) FEUP

Revista

Título: Anticancer Research

Nº de Série 3 Vol. 38

Páginas: 1461-1466

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 25 Citações

Scopus - 36 Citações

Projetos Associados

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Outras Informações

ID Authenticus: P-00N-R0C

DOI: 10.21873/anticanres.12371

Abstract (EN): Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. Materials and Methods: Six-week - old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16(-/-) no treatment, n=12; HPV16(+/-) no treatment, n=13; HPV16(+/-) rutin, n=12; HPV16(+/-) curcumin, n=13. HPV16-induced skin lesions and their inflammatory infiltrates were studied histologically. COX2 expression was assessed immunohistochemically. Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). Curcumin led to dermal and epidermal scores of 10.5 and 4.5. Both compounds reduced leukocytic infiltration, but neither prevented epidermal dysplasia. Conclusion: COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. However, this was not sufficient to block carcinogenesis, calling for additional studies focused on combination therapies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6