Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

C. Adlhart (Autor) Outra; J. Verran (Autor) Outra; N. F. Azevedo (Autor) FEUP; H. Olmez (Autor) Outra; M. M. Keinänen-Toivola (Autor) Outra; I. Gouveia (Autor) Outra; Luís F. Melo (Autor) FEUP; F. Crijns (Autor) Outra

Revista

Título: Journal of Hospital Infection

Vol. 99 Nº 3

Páginas: 239-249

ISSN: 0195-6701

Editora: Elsevier

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 87 Citações

Projetos Associados

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Outras Informações

ID Authenticus: P-00N-R32

DOI: 10.1016/j.jhin.2018.01.018

Abstract (EN): The spread of infections in healthcare environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (e.g. implants, catheters), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc., or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. This review addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated with the implementation of such anti-contamination measures. Different chemistry-based approaches are discussed, for instance anti-adhesive surfaces (e.g. superhydrophobic, zwitterions), contact-killing surfaces (e.g. polymer brushes, phages), and biocide-releasing surfaces (e.g. triggered release, quorum sensing-based systems). The review also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (e.g. toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability) when developing and implementing antimicrobial surfaces. (C) 2018 The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11