The Genetics of Papillary Microcarcinomas of the Thyroid: Diagnostic and Prognostic Implications

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Rodrigues, AC (Autor) Outra; Penna, G (Autor) Outra; Rodrigues, E (Autor) Outra; Castro, P (Autor) Outra; Sobrinho Simoes, M (Autor) Outra; Soares, P (Autor) FMUP

Revista

Título: Current Genomics

Vol. 18

Páginas: 244-254

ISSN: 1389-2029

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 21 Citações

Outras Informações

ID Authenticus: P-00N-F9S

DOI: 10.2174/1389202918666170105094459

Abstract (EN): Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thyroid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small subset may display a potentially aggressive behavior. Nevertheless, we still lack an accurate way of predicting those which will cause significant disease. In an attempt to address this problem, a number of clinico-pathologic features have been studied as poor prognostic markers in mPTC, and their association with known genetic alterations in thyroid cancer has been evaluated. Herein we review the present knowledge concerning mPTC's genetic profile, namely the prevalence of BRAF (V600E), RAS and TERT promoter mutations and RET/PTC and PAX8-PPARG rearrangements and report the results of the evaluation in the putative prognostic value of these genetic alterations in mPTC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11