Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Rodrigues, ARO (Autor) Outra; Mendes, PMF (Autor) Outra; Silva, PML (Autor) Outra; Machado, VA (Autor) Outra; Almeida, BG (Autor) Outra; araujo, j. p. (Autor) FCUP; Queiroz, MJRP (Autor) Outra; Castanheira, EMS (Autor) Outra; Coutinho, PJG (Autor) Outra

Revista

Título: Colloids and Surfaces B: Biointerfaces

Vol. 158

Páginas: 460-468

ISSN: 0927-7765

Editora: Elsevier

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-00N-6GM

DOI: 10.1016/j.colsurfb.2017.07.015

Abstract (EN): Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9