Separations of chiral aryl alcohol derivatives on the (+)- and (-)-hexahelicen-7-yl acetic acid bonded phases

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Del Alamo, A (Autor) Outra; Grieb, S (Autor) Outra; Tiritan M.E. (Autor) FFUP; Matlin, S (Autor) Outra

Revista

Título: Chirality

Vol. 11

Páginas: 416-419

ISSN: 0899-0042

Editora: Wiley-Blackwell

Indexação

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Outras Informações

ID Authenticus: P-001-5EN

DOI: 10.1002/(sici)1520-636x(1999)11:5/6<416::aid-chir11>3.0.co;2-h

Abstract (EN): This paper describes the synthesis of (+)- and (-)-hexahelicen-7 yl acetic acid bonded phases using two bonding reagents. The relationship between the structure of a series of DNB derivatives of chiral aryl alcohols and their enantioselectivity on the (+)-hexahelicen-7-yl acetic acid bonded phase is presented. The DNB derivatives were selected to reflect a range of alkyl side chain lengths, spacer chain lengths between the chiral centre, and the aromatic group and the aromatic group size. The resolution increases with increasing length of the alkyl chain at the chiral centre and decreases on increasing the distance between the aromatic group and the chiral centre. It was confirmed that the enantiomer elution order reverses when changing from the (+)- to the (-)-hexahelicene phase. Chirality 11:416-419, 1999. (C) 1999 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4