New chiral stationary phases based on xanthone derivatives for liquid chromatography

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Carla Fernandes (Autor) FFUP; Tiritan M.E. (Autor) FFUP; Sara Cravo (Autor) FFUP; Phyo, YZ (Autor) Outra; Kijjoa, A (Autor) Outra; Silva, AMS (Autor) Outra; Cass, QB (Autor) Outra; Pinto, MMM (Autor) Outra

Revista

Título: Chirality

Vol. 29

Páginas: 430-442

ISSN: 0899-0042

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-00N-NH2

DOI: 10.1002/chir.22706

Abstract (EN): Six chiral derivatives of xanthones (CDXs) were covalently bonded to silica, yielding the corresponding xanthonic chiral stationary phases (XCSPs). The new XCSPs were packed into stainless-steel columns with 150 x 4.6 mm i.d. Moreover, the greening of the chromatographic analysis by reducing the internal diameter (150 x 2.1 mm i.d.) of the liquid chromatography (LC) columns was also investigated. The enantioselective capability of these phases was evaluated by LC using different chemical classes of chiral compounds, including several types of drugs. A library of CDXs was evaluated in order to explore the principle of reciprocity as well as the chiral self-recognition phenomenon. The separation of enantiomeric mixtures of CDXs was investigated under multimodal elution conditions. The XCSPs provided high specificity for the enantiomeric mixtures of CDXs evaluated mainly under normal-phase elution conditions. Furthermore, two XCSPs were prepared with both enantiomers of the same xanthonic selector in order to confirm the inversion order elution.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13