Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Phyo, YZ (Autor) Outra; Sara Cravo (Autor) FFUP; Palmeira, A (Autor) FFUP; Tiritan M.E. (Autor) FFUP; Kijjoa, A (Autor) Outra; Pinto, MMM (Autor) Outra; Carla Fernandes (Autor) FFUP

Revista

Título: Molecules

Nº de Série 9 Vol. 23 Nº 2288

Página Final: 142

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 36 Citações

Outras Informações

ID Authenticus: P-00N-GTX

DOI: 10.3390/molecules23010142

Abstract (EN): A systematic study of enantioresolution of a library of xanthonic derivatives, prepared in-house, was successfully carried out with four commercially available macrocyclic glycopeptide-based columns, namely Chirobiotic(TM) T, Chirobiotic(TM) R, Chirobiotic(TM) V and Chirobiotic(TM) TAG. Evaluation was conducted in multimodal elution conditions: normal-phase, polar organic, polar ionic and reversed-phase. The effects of the mobile phase composition, the percentage of organic modifier, the pH of the mobile phase, the nature and concentration of different mobile phase additives on the chromatographic parameters are discussed. Chirobiotic(TM) T and Chirobiotic(TM) V, under normal-phase and reversed-phase modes, respectively, presented the best chromatographic parameters. Considering the importance of understanding the chiral recognition mechanisms associated with the chromatographic enantioresolution, and the scarce data available for macrocyclic glycopeptide-based columns, computational studies by molecular docking were also carried out.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22