Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Nascimento, AV (Autor) Outra; Gattacceca, F (Autor) Outra; Singh, A (Autor) Outra; Bousbaa, H (Autor) Outra; Ferreira, DC (Autor) FFUP; Sarmento, B (Autor) Outra; Amiji, MM (Autor) Outra

Revista

Título: Nanomedicine

Vol. 11

Páginas: 767-781

ISSN: 1743-5889

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 32 Citações

Outras Informações

ID Authenticus: P-00K-BW5

DOI: 10.2217/nnm.16.14

Abstract (EN): Background: The present study focuses on biodistribution profile and pharmacokinetic parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for siRNA/cisplatin combination therapy of lung cancer. Material & methods: Mad2 siRNA was encapsulated in EGFR targeted and nontargeted (NTG) CS nanoparticles by electrostatic interaction. The biodistribution of the nanoparticles was assessed qualitatively and quantitatively in cisplatin (DDP) sensitive and resistant lung cancer xenograft model. Results: TG nanoparticles showed a consistent and preferential tumor targeting ability with rapid clearance from the plasma to infiltrate and sustain within the tumor up to 96 h. They exhibit a sixfold higher tumor targeting efficiency compared with the NTG nanoparticles. Conclusion: TG nanoparticles present as an attractive drug delivery platform for RNAi therapeutics against NSCLC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15