MicroRNAs Expression Profiles in Cardiovascular Diseases

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Bronze da Rocha, E (Autor) FFUP

Revista

Título: BioMed Research International

Vol. 2014

Páginas: 1-23

ISSN: 2314-6133

Editora: Hindawi

Indexação

ISI Web of Knowledge - 134 Citações

Scopus - 142 Citações

Outras Informações

ID Authenticus: P-009-NWQ

DOI: 10.1155/2014/985408

Abstract (EN): The current search for new markers of cardiovascular diseases (CVDs) is explained by the high morbidity and mortality still observed in developed and developing countries due to cardiovascular events. Recently, microRNAs (miRNAs or miRs) have emerged as potential new biomarkers and are small sequences of RNAs that regulate gene expression at posttranscriptional level by inhibiting translation or inducing degradation of the target mRNAs. Circulating miRNAs are involved in the regulation of signaling pathways associated to aging and can be used as novel diagnostic markers for acute and chronic diseases such as cardiovascular pathologies. This review summarizes the biogenesis, maturation, and stability of miRNAs and their use as potential biomarkers for coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 23