Effects of resveratrol on the structure and fluidity of lipid bilayers: a membrane biophysical study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Neves, AR (Autor) Outra; Nunes, C (Autor) Outra; Amenitsch, H (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Soft Matter

Vol. 12

Páginas: 2118-2126

ISSN: 1744-683X

Editora: Royal Society of Chemistry

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-00K-6VA

DOI: 10.1039/c5sm02905h

Abstract (EN): Resveratrol is a natural active compound which has been attracting increasing interest due to its several pharmacological effects in cancer prevention, cardiovascular protection and treatment of neuro-degenerative disorders and diabetes. The current work investigates how resveratrol affects membrane order and structure, gathering information determined by X-ray scattering analysis, derivative spectrophotometry, fluorescence quenching and fluorescence anisotropy studies. The results indicate that resveratrol is able to be incorporated into DMPC liposome model systems, either fluidizing or stiffening the bilayer, which largely depends on the membrane fluidity state. These findings suggest that the effects of resveratrol resemble cholesterol action on biological membranes, thereby contributing to the regulation of cell membrane structure and fluidity, which may influence the activity of transmembrane proteins and hence control the cell signaling pathways. The regulation of a number of cellular functions, thus may contribute to the pharmacological and therapeutic activities of this compound, explaining its pleiotropic action.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9