The triad psoriasis-obesity-adipokine profile

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Coimbra, S (Autor) Outra; Cristina Catarino (Autor) FFUP; Alice Santos Silva (Autor) FFUP

Revista

Título: Journal of the European Academy of Dermatology and Venereology

Vol. 30

Páginas: 1876-1885

ISSN: 0926-9959

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 29 Citações

Outras Informações

ID Authenticus: P-00M-78P

DOI: 10.1111/jdv.13701

Abstract (EN): Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro- and anti-inflammatory adipokines in obesity, contributes to the development of a chronic low-grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment. In this review, we will debate published data concerning the current knowledge about the triad psoriasis-obesity-adipokine profile.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10