In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Honorina Cidade (Autor) FFUP; Rocha, V (Autor) Outra; Palmeira, A (Autor) FFUP; Marques, C (Autor) Outra; Tiritan M.E. (Autor) FFUP; Ferreira, H (Autor) Outra; Sousa Lobo JM (Autor) FFUP; Almeida, IF (Autor) FFUP; Emilia Sousa (Autor) FFUP; Pinto, M (Autor) Outra

Revista

Título: Arabian Journal of Chemistry

Vol. 13

Páginas: 17-26

ISSN: 1878-5352

Editora: King Saud University

Indexação

ISI Web of Knowledge - 28 Citações

Scopus - 23 Citações

Outras Informações

ID Authenticus: P-00N-GBQ

DOI: 10.1016/j.arabjc.2017.01.006

Abstract (EN): Many natural products play important roles as antioxidants and represent useful scaffolds for the development of new agents. Particularly, polyphenols in which oxygenated xanthones can be included have proven their efficacy as antioxidants for several applications. To better understand the antioxidant potential of oxygenated xanthones, a library of twenty mono and di-oxygenated xanthones was investigated. The antioxidant properties were evaluated by their 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radical scavenging effect as well as their inhibitory effect on the prooxidant enzyme myeloperoxidase (MPO). A quantitative structure-activity relationship (QSAR) model predicted the maximal atomic partial charge (Qmax) as the descriptor being implied in the antioxidant activity of the referred xanthones. From the antioxidant screening, emerged the hit compound, 1,2-dihydroxyxanthone (10), that was further characterized for its chelating properties and its effect on a human keratinocyte cell line. Taken together, the results suggest the possible effectiveness of xanthone derivatives as antioxidants with potential for topical administration. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10