Strategies to Overcome Heparins' Low Oral Bioavailability

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Neves, AR (Autor) Outra; Marta Correia da Silva (Autor) FFUP; Emilia Sousa (Autor) FFUP; Pinto, M (Autor) Outra

Revista

Título: Pharmaceuticals

Vol. 9

Página Final: 37

ISSN: 1424-8247

Editora: MDPI

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 25 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00K-MH1

DOI: 10.3390/ph9030037

Abstract (EN): Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over parenteral administration. Several approaches emerged, such as conjugation of heparins with bile acids and lipids, formulation with penetration enhancers, and encapsulation of heparins in micro and nanoparticles. Some of these strategies appear to have potential as good delivery systems to overcome heparin's low oral bioavailability. Nevertheless, none have reached the market yet. Overall, this review aims to provide insights regarding the oral bioavailability of heparin.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16