Sources and biological activities of marine sulfated steroids

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Carvalhal, F (Autor) Outra; Marta Correia da Silva (Autor) FFUP; Emilia Sousa (Autor) FFUP; Pinto, M (Autor) Outra; Kijjoa, A (Autor) Outra

Revista

Título: Journal of Molecular Endocrinology

Vol. 61

Páginas: T211-T231

ISSN: 0952-5041

Editora: BioScientifica Ltd.

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 33 Citações

Outras Informações

ID Authenticus: P-00N-GBK

DOI: 10.1530/jme-17-0252

Abstract (EN): Marine environment is rich in structurally unique molecules and can be an inspiring source of novel drugs. Currently, six marine-derived drugs are in the market with FDA approval and several more are in the clinical pipeline. Structurally diverse and complex secondary metabolites have been isolated from the marine world and these include sulfated steroids. Biological activities of nearly 150 marine sulfated steroids reported from 1978 to 2017 are compiled and described, namely antimicrobial, antitumor, cardiovascular and antifouling activities. Structure-activity relationship for each activity is discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21