Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Figueiredo Gonzalez, M (Autor) Outra; Patricia Valentao (Autor) FFUP; David M Pereira (Autor) FFUP; Paula B Andrade (Autor) FFUP

Revista

Título: Food and Chemical Toxicology

Vol. 109

Páginas: 386-392

ISSN: 0278-6915

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-00N-1PB

DOI: 10.1016/j.fct.2017.09.018

Abstract (EN): This study focused the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of tomato plant cultivars (Caramba, Valentine, Negro, Abuela, and Anairis). AE, HME and AcE extracts of all cultivars reduced cell viability, IC50 values ranging from 9 +/- 2 to 55 +/- 11, from 103 +/- 25 to 171 +/- 29 and from 291 +/- 26 to 459 +/- 14 mu g mL(-1), respectively. Moreover, both HME and AcE extracts scavenged (NO)-N-center dot (IC50 values ranged from 0.87 +/- 0.12 to 1.54 +/- 0.23 and from 0.90 +/- 0.01 to 2.23 +/- 0.14 mg mL(-1), respectively), but only HMEs was able to scavenge O-2(center dot-) showing IC50 values from 0.12 +/- <= 0.01 to 0.43 +/- 0.08 mg mL(-1). Our results demonstrate that tomato leaves, a by-product of tomato processing industry, are a valuable source of bioactive compounds, providing beneficial properties for human health.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7