Prognostic factors in an exercised model of chemically-induced mammary cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Antonieta Alvarado (Autor) Outra; Ana I. Faustino-Rocha (Autor) Outra; Rita Ferreira (Autor) Outra; Rafael Mendes (Autor) Outra; José Alberto Duarte (Autor) FADEUP; Maria João Pires (Autor) Outra; Bruno Colaço (Autor) Outra; Paula A. Oliveira (Autor) Outra

Revista

Título: Anticancer Research

Vol. 36 Nº 5

Páginas: 2181-2188

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 7 Citações

Classificação Científica

FOS: Ciências sociais

Outras Informações

ID Authenticus: P-00K-FHV

Abstract (EN): Background/Aim: Estrogen receptor alpha ( ER alpha) and Ki-67 are strong prognostic and predictive markers in woman breast cancer. This study aimed to evaluate the immunoexpression of prognostic factor markers ER alpha, Ki-67 proliferation index (Ki-67 PI) and the mitotic activity index (MAI) in mammary tumors induced by 1-methyl-1-nitrosourea (MNU) in female Sprague-Dawley rats submitted to lifelong exercise training. Materials and Methods: Thirty female rats were injected with MNU and randomly divided into two groups: sedentary and exercised. Results: All neoplasms from both groups were ER alpha-positive with an H-score >= 20. Statistically significant differences were not found in the ER alpha H-score, Ki-67 PI and MAI between groups. The absolute value of ER alpha H-score was higher in the exercised group, while the Ki-67 PI and MAI were higher in the sedentary group. Conclusion: Tumors from the exercised group were less proliferative and more differentiated, suggesting that long-term exercise training had positive effects on mammary carcinogenesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8