The NF kappa B Signaling Pathway in Papillomavirus-induced Lesions: Friend or Foe?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Rui M. Gil Da Costa (Autor) Outra; Margarida M. S. M. Bastos (Autor) FEUP; Rui Medeiros (Autor) ICBAS; Paula A. Oliveira (Autor) Outra

Revista

Título: Anticancer Research

Vol. 36 Nº 5

Páginas: 2073-2083

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 48 Citações

Outras Informações

ID Authenticus: P-00K-FHT

Abstract (EN): Papillomaviruses induce a range of benign and malignant lesions in their hosts, including cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The nuclear factor kappa-light-chain-enhancer of activated B-cells (NF kappa B) plays a pivotal role in HPV-infected cells, and its expression and activity are modulated by several viral oncoproteins. NF kappa B modulation seems to first facilitate viral persistence and immune evasion, and later to drive tumour progression, but the many conflicting results and the complexity of its signaling networks require great prudence while interpreting the role of NF kappa B in papillomaviral lesions. Accordingly, the pharmacological targeting of the NF kappa B pathway in HPV-induced lesions is a complex and currently unmet challenge. This review deals with recent findings concerning NF kappa B activation in HPV-infected cells, its role in viral persistence, cell transformation and tumour progression, and with current efforts to target this pathway for cancer prevention and therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11