Exploring the Solid-Phase Synthesis of Sulfotyrosine Peptides

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Nuno Vale (Autor) FCUP; Veloso, RC (Autor) Outra; Paula Gomes (Autor) FCUP

Revista

Título: European Journal of Organic Chemistry

Vol. 2015

Páginas: 7413-7425

ISSN: 1434-193X

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00J-YXP

DOI: 10.1002/ejoc.201500715

Abstract (EN): Tyrosine sulfation is a common post-translational modification operative in many biological processes, including hemostasis and intracellular trafficking. However, the precise structural and functional role of sulfotyrosine residues is not fully understood, so there is a demand for further detailed studies on the role of tyrosine sulfation in biochemical processes. Unfortunately, studies on the biological roles of tyrosine sulfation are hampered by difficulties in gaining access to large quantities of high-purity and homogeneous sulfoproteins and sulfopeptides. This, however, may be addressed by appropriate solid-phase peptide synthesis strategies, and these constitute the core subject of this review. An overview of efficient approaches to the synthesis of sulfopeptides and their associated pros and cons is presented.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13