Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Couto, D (Autor) Outra; Freitas, M (Autor) Outra; Costa, VM (Autor) Outra; Chiste, RC (Autor) Outra; Agostinho Almeida (Autor) FFUP; Lopez Quintela, MA (Autor) Outra; Rivas, J (Autor) Outra; Freitas, P (Autor) Outra; Silva, P (Autor) Outra; Felix Carvalho (Autor) FFUP; Eduarda Fernandes (Autor) FFUP

Revista

Título: Journal of Applied Toxicology

Vol. 36

Páginas: 1321-1331

ISSN: 0260-437X

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 26 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00K-QHB

DOI: 10.1002/jat.3323

Abstract (EN): Iron oxide nanoparticles (IONs) have physical and chemical properties that render them useful for several new biomedical applications. Still, so far, in vivo safety studies of IONs with coatings of biomedical interest are still scarce. The aim of this study, therefore, was to clarify the acute biological effects of polyacrylic acid (PAA)-coated IONs, by determining their biodistribution and their potential proinflammatory and toxic effects in CD-1 mice. The biodistribution of PAA-coated IONs in several organs (liver, spleen, kidneys, brain, heart, testes and lungs), the plasma cytokines, chemokine and aminotransferases levels, white blood cell count, oxidative stress parameters, adenosine triphosphate and histologic features of liver, spleen and kidneys were evaluated 24h after a single acute (8, 20 or 50mgkg(-1)) intravenous administration of PAA-coated IONs in magnetite form. The obtained results showed that these IONs accumulate mainly in the liver and spleen and, to a lesser extent, in the lungs. Although our data showed that PAA-coated IONs do not cause severe organ damage, an inflammatory process was triggered in vivo, as evidenced by as evidenced by increased neutrophils and large lymphocytes in the differential blood count. Moreover, an accumulation of iron in macrophages of the liver and spleen was observed and hepatic lipid peroxidation was elicited, showing that the IONs are able to induce oxidative stress. The effects of these nanoparticles need to be further investigated regarding the mechanisms involved and the long-term consequences of intravenous administration of PAA-coated IONs. Copyright (c) 2016 John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11