Electrochemical behaviour of Venlafaxine and its determination in pharmaceutical products using square wave voltammetry

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Lima, JLFC (Autor) FFUP; Loo, DV (Autor) Outra; Delerue Matos, C (Autor) Outra; da Silva, ASR (Autor) Outra

Revista

Título: Farmaco

Vol. 54

Páginas: 145-148

ISSN: 0014-827X

Editora: Elsevier B.V.

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-001-4T9

DOI: 10.1016/s0014-827x(99)00007-5

Abstract (EN): An electrochemical method for the determination of Venlafaxine in pharmaceutical formulations recently available on the European market is described. The electrochemical oxidation of Venlafaxine was studied at a HMDE electrode over a wide pH range (1.9-10.0) of buffered aqueous solutions using different potential sweep techniques. The results obtained showed that the best definition of the analytical signals was found in boric acid/potassium tetrahydroxoborate buffer at pH 8.7 using anodic stripping square wave voltammetry. Recovery trials were performed to assess the accuracy of results and these were compared to those provided by a HPLC technique according to the method described in literature and to the features of the pharmaceutical formulations. A relative deviation of < 0.2% was obtained. With the developed methodology, the limit of detection was 0.124 mg/l.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4