The NFkB signaling pathway in papillomavirus-induced lesions: Friend or foe?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Rui M. Gil da Costa (Autor) FEUP; Margarida M. S. M. Bastos (Autor) FEUP; Rui Medeiros (Autor) Outra; Paula A. Oliveira (Autor) Outra

Revista

Título: Anticancer Research

Páginas: 2073-2084

ISSN: 0250-7005

Editora: International Institute of Anticancer Research

Indexação

ISI Web of Science

Projetos Associados

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Outras Informações

ID Authenticus: P-010-VFC

Abstract (EN): Papillomaviruses induce a range of benign and malignant lesions in their hosts, including cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The nuclear factor kappa-light-chain-enhancer of activated B-cells (NF¿B) plays a pivotal role in HPV-infected cells, and its expression and activity are modulated by several viral oncoproteins. NF¿B modulation seems to first facilitate viral persistence and immune evasion, and later to drive tumour progression, but the many conflicting results and the complexity of its signaling networks require great prudence while interpreting the role of NF¿B in papillomaviral lesions. Accordingly, the pharmacological targeting of the NF¿B pathway in HPV-induced lesions is a complex and currently unmet challenge. This review deals with recent findings concerning NF¿B activation in HPVinfected cells, its role in viral persistence, cell transformation and tumour progression, and with current efforts to target this pathway for cancer prevention and therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12