Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus)

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Gil da Costa, R. M. (Autor) ICBAS; Rema, A (Autor) Outra; Payo Puente, P (Autor) Outra; Gaertner, E (Autor) Outra

Revista

Título: Journal of Comparative Pathology

Vol. 137

Páginas: 130-132

ISSN: 0021-9975

Editora: Elsevier

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-004-8G5

DOI: 10.1016/j.jcpa.2006.04.006

Abstract (EN): Sebaceons gland carcinoma is a common tumour in male gerbils but, to date, no information is available on its immunohistochemical properties. This report describes the histopathological and immunohistochemical features of such a tumour from a 4.5-year-old male gerbil. The tumour immunoreactivity profile was studied in respect of p53 protein, CEA, EMA, c-erbB-2, cytokeratin (CK) 14 and the CKs detected by AE1/AE3 antibodies (i.e. high molecular weight CKs 1. 2, 3, 4, 5, 6 10 14 1,5 and 16, and low; molecular weight, CKs 7, 8 and 19). The differences observed in p53 and c-erbB-2 immunolabelling between carcinomatous and hyperplastic areas suggest that p53 mutations and amplification of c-erb-B-2 may play a significant role in the oncogenesis of sebaceous gland carcinoma in the gerbil.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3