Estimation of rat mammary tumor volume using caliper and ultrasonography measurements

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

A. Faustino Rocha (Autor) Outra; P. A. Oliveira (Autor) Outra; J. Pinho Oliveira (Autor) Outra; C. Teixeira Guedes (Autor) Outra; R. Soares Maia (Autor) Outra; R. M. Gil da Costa (Autor) FEUP; B. Colaco (Autor) Outra; M.J. Pires (Autor) Outra; J. Colaco (Autor) Outra; R. Ferreira (Autor) Outra; M. Ginja (Autor) Outra

Revista

Título: Lab Animal

Vol. 42 Nº 6

Páginas: 217-224

ISSN: 0093-7355

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 12 Citações

Projetos Associados

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Outras Informações

ID Authenticus: P-005-06Q

DOI: 10.1038/laban.254

Abstract (EN): Mammary tumors similar to those observed in women can be induced in rats by intraperitoneal administration of N-methyl-N-nitrosourea. Determining tumor volume is a useful and quantitative way to monitor tumor progression. In this study, the authors measured dimensions of rat mammary tumors using a caliper and using real-time compound B-mode ultrasonography. They then used different formulas to calculate tumor volume from these tumor measurements and compared the calculated tumor volumes with the real tumor volume to identify the formulas that gave the most accurate volume calculations. They found that caliper and ultrasonography measurements were significantly correlated but that tumor volumes calculated using different formulas varied substantially. Mammary tumors seemed to take on an oblate spheroid geometry. The most accurate volume calculations were obtained using the formula V = (W-2 x L)/2 for caliper measurements and the formula V = (4/3) x pi x (L/2) x (L/2) x (D/2) for ultrasonography measurements, where V is tumor volume, W is tumor width, L is tumor length and D is tumor depth.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8