Transthyretin regulates hippocampal 14-3-3 zeta protein levels

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Vieira, M (Autor) Outra; Maria Joao Saraiva (Autor) ICBAS

Revista

Título: FEBS Letters

Vol. 587

Páginas: 1482-1488

ISSN: 0014-5793

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-005-0P9

DOI: 10.1016/j.febslet.2013.03.011

Abstract (EN): Transthyretin is the carrier protein of thyroxine and retinol in plasma and cerebrospinal fluid and has been described also as a neuroprotective molecule. 14-3-3 Proteins are very important in many cellular processes, being their absence related with deficits in memory and learning. The analysis of the relationship between these two proteins is the main objective of this work. We found that hippocampi of young TTR null mice presented lower levels of 14-3-3 zeta protein, but no changes in gene expression when compared to TTR wild type littermates were noted. Cellular studies ascribed this finding to increased degradation of 14-3-3 zeta in lysosomes in the absence of TTR, increasing autophagy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7