In vitro effect of fibrinogen on Candida albicans germ tube formation

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

rodrigues, ag (Autor) FMUP; pina-vaz, c (Autor) FMUP; Mardh, PA (Autor) Outra; Da Fonseca, AF (Autor) Outra; De Oliveira, JM (Autor) Outra

Revista

Título: Infectious Diseases in Obstetrics and Gynecology

Vol. 107

Páginas: 1020-1022

ISSN: 1064-7449

Editora: Hindawi

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-001-2WF

DOI: 10.1155/s1064744994000074

Abstract (EN): Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen, The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated iu the presence of serial concentrations of fraction I, type TV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3