INTRAVITREAL RANIBIZUMAB FOR MYOPIC CHOROIDAL NEOVASCULARIZATION 12-Month Results

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Silva, RM (Autor) Outra; Ruiz Moreno, JM (Autor) Outra; Rosa, P (Autor) Outra; Ângela Carneiro (Autor) FMUP; Nascimento, J (Autor) Outra; Rito, LF (Autor) Outra; Cachulo, ML (Autor) Outra; Carvalheira, F (Autor) Outra; Murta, JN (Autor) Outra

Revista

Título: Retina

Vol. 30

Páginas: 407-412

ISSN: 0275-004X

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 71 Citações

Scopus - 80 Citações

Outras Informações

ID Authenticus: P-003-906

DOI: 10.1097/iae.0b013e3181c9691e

Abstract (EN): Purpose: The purpose of this study was to evaluate the safety and efficacy of intravitreal ranibizumab after 12 months in the treatment of choroidal neovascularization secondary to pathologic myopia. Methods: This was a prospective, multicenter, consecutive, nonrandomized, interventional case series. The study included 34 eyes of 32 patients with choroidal neovascularization secondary to pathologic myopia; 13 eyes had previous photodynamic therapy, and 21 eyes had no previous treatment. The patients were followed for >= 12 months. Best-corrected visual acuity, optical coherence tomography, and the presence of metamorphopsia were assessed monthly. Results: Mean visual acuity improved 8 letters from baseline to 12-month follow-up, and the difference was statistically significant (P < 0.001): 100% of the eyes lost <3 lines on the Early Treatment Diabetic Retinopathy Study chart, 24% of the eyes improved >= 3 lines, 44% improved >= 2 lines, 65% improved >= 1 line, and 79% improved >= 0 lines. Central retinal thickness decreased significantly from baseline to the 12-month follow-up (P < 0.01). A mean of 3.6 treatments were performed during the 12-month follow-up, and no systemic or ocular side effects were registered during that time. Conclusion: One-year results of intravitreal ranibizumab for myopic choroidal neovascularization are very promising. Additional prospective studies are necessary to better determine long-term efficacy and safety. RETINA 30: 407-412, 2010

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6