Molecular targets and biological modifiers in gastric cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Carneiro F (Autor) FMUP; Oliveira C (Autor) FMUP; Marina Leite (Autor) Outra; Seruca, R (Autor) FMUP

Revista

Título: Seminars in Diagnostic Pathology

Vol. 25 Nº 4

Páginas: 274-287

ISSN: 0740-2570

Editora: Elsevier

Indexação

ISI Web of Knowledge - 26 Citações

Scopus - 30 Citações

Outras Informações

ID Authenticus: P-003-VCZ

DOI: 10.1053/j.semdp.2008.07.004

Abstract (EN): The overall survival of gastric cancer patients remains poor despite efforts and advances in its prevention, diaposis, and treatment. The development of new therapies is crucial for the effective control of this disease. An increasing number of genetic and epigenetic alterations have been associated with distinct histological types of gastric cancer. In this review, we will discuss the involvement of E-cadherin, EGFR, ERBB2, MMR genes, KRAS, and PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets for therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14