SIGNET RING CELL-CARCINOMA OF THE STOMACH - A MORPHOMETRIC, ULTRASTRUCTURAL, AND DNA CYTOMETRIC STUDY

• Tipo: Artigo em Revista Científica Internacional
• Data: 1992

Autores

Carneiro F (Autor) FMUP; MOUTINHORIBEIRO, M (Autor) Outra; David L (Autor) FMUP; SEIXAS, M (Autor) Outra; SANSONETTY, F (Autor) Outra; Soares, P (Autor) Outra; SERRANO, A (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: Ultrastructural Pathology

Vol. 16

Páginas: 603-614

ISSN: 0191-3123

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 25 Citações

Outras Informações

ID Authenticus: P-001-P2Z

Abstract (EN): The present study was undertaken to determine whether or not signet ring cell (diffuse, isolated cell) gastric carcinomas display a specific profile at the ultrastructural, morphometric, and DNA cytometric levels. Thirty-two cases of gastric carcinoma and 8 cases of peptic ulcer (control group) were studied with electron microscopy, morphometry, flow cytometry, and image cytometry. Despite the ultrastructural cellular heterogeneity of signet ring cell carcinomas, the neoplastic cells display fairly constant morphometric features: The cellular and nuclear volumes are significantly smaller than those of the other types of gastric carcinomas and closely resemble those of normal foveolar cells. The relatively small size of signet ring cell carcinoma nuclei fits with the high percentage of the cases of this type of gastric carcinoma that are either diploid or nearly diploid. There is a relationship between the infiltrative pattern of growth of gastric carcinoma (regardless of histologic subtype and ultrastructural cell differentiation) and the small size of neoplastic cells and their nuclei.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12