Placental findings in fetuses with absent or reversed end-diastolic flow in the umbilical artery (ARED flow): A reappraisal

• Tipo: Artigo em Revista Científica Internacional
• Data: 1997

Autores

Montenegro N (Autor) FMUP; Laurini, R (Autor) Outra; Brandao, O (Autor) Outra; Nogueira, R (Autor) Outra; matias, a (Autor) FMUP; Santos, F (Autor) Outra; Barros H (Autor) FMUP

Revista

Título: Journal of Maternal-Fetal Investigation

Vol. 7

Páginas: 175-179

ISSN: 0939-6322

Editora: Springer

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 10 Citações

Outras Informações

ID Authenticus: P-001-ASW

Abstract (EN): Objective: To make the reappraisal of the specific placental changes associated with absent or reversed end-diastolic flow (ARED flow) in order to clarify the pathophysiological background of such high risk pregnancies. Methods: In a total of 42 high risk pregnancies in the same gestational age range, a prospective evaluation of 28 cases of ARED (20 cases of absent (AED) and 8 cases of reversed (RED)) and 14 cases of present umbilical end-diastolic flow used as a control group was performed. All the placentas were referred for pathological examination using a previously designed protocol, Results: Correlation between morphological and Doppler flow findings was significant for infarction and massive perivillous fibrin deposition versus ARED flow and intrauterine growth retardation, There was a statistically significant difference in placental and fetal weights between the ARED and control groups. Fetal, neonatal, and postneonatal deaths occurred in 15 cases of the ARED group and in 1 case of the control group. Conclusions: ARED flow is clearly associated with prominent placental histological lesions, namely infarction and massive perivillous fibrin deposition. Such alterations can be related to a high downstream vascular impedance or resistance, intrauterine growth retardation, and hypoxia.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5