Hypertension due to chronic blockade of P-I-purinoceptors

• Tipo: Artigo em Revista Científica Internacional
• Data: 1996

Autores

Guimaraes, S (Autor) Outra; Albino Teixeira, A (Autor) FMUP

Revista

Título: Journal of Autonomic Pharmacology

Vol. 16

Páginas: 367-370

ISSN: 0144-1795

Editora: Blackwell

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-001-DA5

DOI: 10.1111/j.1474-8673.1996.tb00055.x

Abstract (EN): I Long-term treatment of rats with 1,3-dipropyl-8-sulphophenylxanthine (DPSPX), a nonselective antagonist of adenosine receptors, causes a hypertensive state. 2 In DPSPX-hypertensive rats, prejunctional alpha(2)-adrenoceptors become supersensitive to the selective alpha(2)-adrenoceptor agonist UK-14,304, while postjunctional adrenoceptor-mediated responses are not changed; furthermore, prejunctional beta-adrenoceptor-mediated facilitation of noradrenaline release is also enhanced. 3 In DPSPX-hypertensive rats, there are important morphological alterations of the small arteries, their lumina appearing strongly reduced and occasionally occluded by proliferation of the intimal cells. 4 In DPSPX-hypertensive rats, there is an increase in plasma renin, and captopril prevents not only the development of the hypertension but also the morphological changes in the arteries. 5 Other important changes occur in DPSPX-hypertensive rats: an alteration of the adrenergic regulation of the cardiac functions and an enhancement of perivascular neurotransmission. 6 These results suggest that adenosine may play an important role in the development of some kinds of human hypertension.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4